Journal
The Research Desk
Articles on peptide science, manufacturing standards, and what we're learning as we build Helix.
How to Read a Peptide Certificate of Analysis (CoA)
How to Read a Peptide Certificate of Analysis (CoA) A Certificate of Analysis is only as useful as the reader's ability to...
Retatrutide: What the Clinical Evidence Actually Shows
The Research Desk A Phase 2 trial reported retatrutide outperforming earlier GLP-1 therapies on weight-loss endpoints, though cross-trial comparisons carry limits. A...
The Incretin-Glucagon Axis: GLP-1, GIP, and Glucagon in Hunger and Energy Homeostasis
Every time you eat a meal, your gut orchestrates a biochemical response of remarkable precision. Within minutes of food entering the small...
MOTS-c: The Peptide Your Mitochondria Make, Not Your Genome
The Research Desk, Helix Almost every signaling peptide studied in metabolic research comes from the same source: a gene in the cell's...
Is Substance P the Next Major Target in Regenerative Research?
This article is written for research and educational purposes only. The compounds, peptides and molecules discussed have not been approved for human...
Brenipatide: The GLP-1/GIP Peptide Lilly Is Betting On for Addiction, Not Just Obesity
The Research Desk, Helix Most of the incretin pipeline built since semaglutide has followed a predictable script: activate GLP-1 receptors, add a...
CJC-1295 and Ipamorelin: Mechanisms of Action, Efficacy Data, and Safety Profile
CJC-1295 and Ipamorelin are almost always used together — and almost always described the same way: they make your body produce more...
Thymosin Beta-4 and TB-500: What the Regenerative Medicine Evidence Actually Supports
TB-500 is a synthetic fragment of Thymosin Beta-4 — a peptide your body already produces after injury. This article examines the preclinical...
BPC-157: What the Preclinical and Early Human Evidence Actually Shows
A naturally-derived peptide with consistent preclinical data on tissue repair, tendon healing, and recovery. Here's what the science actually shows.
Why Some Research Peptides Become Medical Breakthroughs While Others Disappear
Semax, Dihexa, Selank — the marketing promises sharper memory, faster learning, lasting cognitive gains. The science is more nuanced. Here's what the...
Epithalon and the Pineal Gland: A Critical Appraisal of Anti-Aging Mechanisms and Supporting Evidence
Russian gerontologist Vladimir Khavinson built a 50-year case that a peptide from the pineal gland could change how we age. Telomere elongation,...
DSIP: The Sleep Peptide That Has Been Puzzling Neurologists for 40 Years
Discovered in 1977 in the blood of deeply sleeping rabbits, DSIP improved sleep in multiple controlled human trials — and quietly turned...
GHK-Cu in Tissue Repair: Evaluating the Preclinical and Clinical Evidence
GHK-Cu is a copper-binding tripeptide naturally produced by the body — and one of the most studied peptides in existence. This article...
GLP-1 Changed Metabolic Medicine. Could GLP-5 Be Next?
Semaglutide and tirzepatide didn't come from nowhere. They harness three gut peptides — GLP-1, GIP and glucagon — that have been regulating...